Troy Dawson mengumumkan rilis Scientific Linux 5.4, distribusi turunan yang dikompilasi dari kode sumber distro Red Hat Enterprise Linux 5.4 ditambah paket-paket ekstra saintifik, file systems dan software lainnya:
Scientific Linux 5.4 has been released for both i386 and x86_64 architecture. There are packages that we used to have to add to Scientific Linux, that are now in Enterprise 5, and so we do not have to add them ourselves. FUSE, and its kernel modules, are now provided by the upstream vendor. The Atheros wireless chipset is now supported by the upstream vendor. We have added the iwlwifi 5150 ucode (firmware), as well as updated the 3945, 4945, and 5000 ucode. Lua has been also been added to the release. Scientific Linux release 5.4 is based on the rebuilding of RPMs out of SRPMs from Enterprise 5 Server and Client, it also has all errata and bug fixes up until November 1, 2009.